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If you are seeing an error when trying to load your site (and have been able to verify that this is not a temporary local issue via a global Uptime report), it's possible that there is an error at your host, in which case you will need to contact them to check.
Regardless of the error you are seeing, it's a good idea to also check that the DNS records at your host match those you have entered at Ezoic, and that your SSL settings are correct, particularly if you have only just integrated with Ezoic.
If you are still seeing an origin error after confirming that your DNS records and SSL settings are configured correctly, then it's likely that Ezoic IPs are being miscategorized as 'bot traffic' by your host or a security plugin or feature. There are different options to fix this and to help your host accept requests from Ezoic. These can be implemented by your host at your request. More info including the potential solutions can be found here.